Protein Details: Aquaporin AqpM

Protein ID

ICDB_Pro_1461

Protein Name

Aquaporin AqpM

Gene Name

aqpM; MTBMA_c05510

Organism

Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)

Length

246 amino acids

AlphaFoldDB

AF-Q9C4Z5-F1-model_v4.pdb

Function

Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux.

Sequence

MVSLTKRCIAEFIGTFILVFFGAGSAAVTLMIASGGTSPNPFNIGIGLLGGLGDWVAIGLAFGFAIAASIYALGNISGCHINPAVTIGLWSVKKFPGREVVPYIIAQLLGAAFGSFIFLQCAGIGAATVGGLGATAPFPGISYWQAMLAEVVGTFLLMITIMGIAVDERAPKGFAGIIIGLTVAGIITTLGNISGSSLNPARTFGPYLNDMIFAGTNLWNYYPIYVIGPIVGAVLAALTYQYLTSE

PDB Structures

2EVU 2F2B

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1263/jbb.92.488; 10.1128/jb.00844-10; 10.1074/jbc.m212418200

RefSeq

WP_013295370.1